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| ID | Type | Description | Link |
|---|---|---|---|
| P30AG072973 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypertensive disorder of pregnancy | Women who were diagnosed with a hypertensive disorder of pregnancy during the ADORE study participation. |
| |
| Healthy pregnancy | Women who participated in the ADORE study and had a healthy pregnancy during their participation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| A combination of various test and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy in brain health in midlife. | Diagnostic Test | Participants will be asked to complete a blood draw, 5-lead ECG, MRI, a series of cognitive assessments, dietary assessments, monitor sleep and physical activity and DXA scan. |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiometabolic markers of middle age women | Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control. | Baseline |
| Neurovascular hemodynamics of middle age women | Assess differences in heart rate via an ECG, and beat to beat blood pressure, cerebral blood flow, and pulse wave velocity) between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control. | Baseline |
| Brain structure & function of middle age women | Assess differences in MRI MPRAGE, fMRI and DTI sequencing scan between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control. | Baseline |
| Alzheimer's disease-related plasma biomarkers of middle age women | Assess value differences in a predetermined Alzheimer's disease-related plasma biomarkers between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy controls. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Women who previously participated in the ADORE, received a hypertensive disorder diagnosis or had a healthy pregnancy during their participation.
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| Name | Affiliation | Role |
|---|---|---|
| Holly R Hull, PhD | University of Kansas Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 6, 2026 | |
| Reset | Jun 1, 2026 |
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Whole blood
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 6, 2026 | Jun 1, 2026 | |||
| Jun 16, 2026 |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D000544 | Alzheimer Disease |
| D003704 | Dementia |
| D002318 | Cardiovascular Diseases |
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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