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This study will focus on orthopedic surgery patients from high-altitude regions, utilizing smart wearables and monitoring tools to gather perioperative data, including heart rate, oxygen saturation, sleep quality, stress levels, and other relevant metrics. Regular follow-ups will assess recovery and complications, in addition to collecting medical records, lab results, imaging data, and other pertinent records. The ultimate goal is to establish a comprehensive follow-up cohort of orthopedic surgery patients from high-altitude areas.
Prolonged exposure to hypoxic and low-pressure environments leads to structural remodeling and functional abnormalities in the cardiovascular, respiratory, and hematological systems of high-altitude populations. This elevates the risk of postoperative complications, particularly in patients undergoing orthopedic surgery, significantly impacting their recovery and quality of life. This study will focus on orthopedic surgery patients from high-altitude regions. Using smart wearable devices and other monitoring tools, comprehensive perioperative dynamic data of participants, including heart rate, heart rate variability, oxygen saturation, respiratory rate, sleep quality, activity levels, stress index, and other relevant indicators will be collected. Regular follow-ups will be conducted to evaluate postoperative recovery and monitor the incidence of perioperative complications. Additionally, perioperative data such as electronic medical records, laboratory test results, ECG waveforms, echocardiography, chest CT images, and other pertinent records will be also collected. Through that, this study aims to establish a follow-up cohort of orthopedic surgery patients from high-altitude regions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Orthopedic surgery patients from high-altitude regions | high altitude patients Undergoing orthopedic surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative venous thromboembolism | Defined according to the European Perioperative Clinical Outcome (EPCO) criteria, including both deep vein thrombosis and pulmonary embolism. | During hospitalization |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative venous thromboembolism | Defined according to the European Perioperative Clinical Outcome (EPCO) criteria, including both deep vein thrombosis and pulmonary embolism. | Up to 2 weeks postoperatively |
| A composite of postoperative pulmonary complications |
| Measure | Description | Time Frame |
|---|---|---|
| Pain scores of movement-evoked pain | Assessed using NRS scale and BPI at different time points after surgery | During hospitalization |
| Pain scores at rest | Using NRS scale and BPI at different time points after surgery |
Inclusion Criteria:
Exclusion Criteria:
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Patients who have lived in high-altitude regions scheduled for orthopedic surgery.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chunling Jiang, PhD | Contact | +86 02885422114 | jiangchunling@scu.edu.cn | |
| Fengming Luo, phD | Contact | +86 85423593 | jiangchunling@scu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Chunling Jiang, PhD | West China Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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Blood and hair.
Defined according to the European Perioperative Clinical Outcome (EPCO) criteria, including respiratory infection, respiratory failure, pleural effusion, atelectasis, pneumothorax, bronchospasm, and aspiration pneumonia. |
| During hospitalization |
| Postoperative major adverse cardiovascular events | Defined according to the European Perioperative Clinical Outcome (EPCO) criteria, including non-fatal cardiac arrest, acute myocardial infarction, congestive heart failure, new cardiac arrhythmias, angina, et al. | During hospitalization |
| Postoperative nausea and vomiting | Nausea and vomiting | During hospitalization |
| The quality of postoperative recovery | Assessed using QoR-15 score at different time points after surgery | During hospitalization |
| Chronic pain after surgery | Assessed using NRS scale and BPI at different time points after surgery | Up to 1 year postoperatively |
| Postoperative quality of life assessment | Assessed using WHODAS2.0 scores at different time points after surgery | Up to 1 year postoperatively |
| During hospitalization |
| Surgical site infection | Defined according to the European Perioperative Clinical Outcome (EPCO) criteria | During hospitalization |
| Time of Bowel function recovery | Defined as time to first defecation or flatus | During hospitalization |
| Sleep quality after surgery | Assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Morningness-Eveningness Questionnaire (MEQ) at different time points after surgery | Up to 1 year postoperatively |
| Postoperative anxiety assessment | Assessed using GAD-7 scores at different time points after surgery | Up to 1 year postoperatively |
| Postoperative depression assessment | Assessed using PHQ-9 scores at different time points after surgery | Up to 1 year postoperatively |
| Postoperative cognitive function assessment | Assessed using AD-8 and three-word recall test scores at different time points after surgery | Up to 1 year postoperatively |