Effect of Hyaluronic Acid and Single Dose Corticosteroid Injection to Improve Wound Healing in Controlled Diabetic Patients Post Tooth Extraction.

Effects of Hyaluronic Acid and Corticosteroid in Post Extraction Wound Healing of Diabetic Patients

The goal of this clinical trial is to learn if hyaluronic acid and corticosteroid improves wound healing in diabetic patients after oral extraction.

After sample size estimation via Open Epi of 128, randomized clinical trial was performed on the patients from Oral and Maxillofacial Surgery Department in Madinah Teaching Hospital, Faisalabad. Patients were divided into three groups. Group 1 was subjected as control group, Group 2 was treated post extraction with 0.2 % Hyaluronic acid (Gengigel Gingival Gel 20ml, Ricerfarma, Milan, Italy) and Group 3 was treated with single dose Hy-Cortisone Injection 250 mg (Generic name: Hydrocortisone Sodium Succinate, Cirin Pharmaceuticals Pakistan) intramuscularly after extraction. Wound healing was assessed through Landry Healing Index. One-way ANOVA test was applied for comparative analysis and Post Hoc Tuckey's test was applied for pairwise comparisons between the groups

Inclusion Criteria:

• • Controlled diabetic patients who had random blood glucose levels of 80 to 130 mg/dl, according to World Health Organization.

  • Age was defined from 25-55, irrespective of the gender.
  • Tooth extractions in maxilla or mandible without the presence of an acute infection or compromised periodontal state.

Exclusion Criteria:

• • Patients who declined to participate.

  • Patients below the age of 25 and above the age of 55.
  • Patients with uncontrolled diabetes mellitus (blood sugar levels high than the defined range)
  • Patients with history of adverse effects to local anesthetics or who are currently taking corticosteroids.
  • Patients with unmaintained oral hygiene and smoking habits.
  • Confirmation of any chronic illness, including those with hypertension or cardiac disorders.
  • Patients who have undergone any recent major surgical procedure.