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The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a "Nanodropper" adaptor. The Nanodropper is designed to administer smaller-sized drops, or microdrops.
Participants will:
This study could help us find a way to use less medication while still effectively administering eye medications, potentially saving money and reducing medical waste.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard Eye Drops | Active Comparator | Eyes randomized to this arm will receive a standard drop of 0.5% proparacaine HCl |
|
| Nanodropper | Experimental | Eyes randomized to this arm will receive a Nanodropper-mediated microdrop of 0.5% proparacaine HCl |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nanodropper and Proparacaine HCl 0.5% | Combination Product | The Nanodropper is an eyedrop bottle adaptor that creates smaller eyedrops by coupling to an existing eyedrop bottle. This intervention involves the administration of proparacaine HCl 0.5% using the Nanodropper. |
| Measure | Description | Time Frame |
|---|---|---|
| Corneal Anesthesia | The primary outcome is the percent or proportion of subjects that achieve anesthesia at the 5-minute time point | 5 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Columbia University Irving Medical Center | New York | New York | 10032 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37056302 | Background | St Peter DM, Steger JS, Patnaik JL, Davis N, Kahook MY, Seibold LK. Reduction of Eyedrop Volume for Topical Ophthalmic Medications with the Nanodropper Bottle Adaptor. Med Devices (Auckl). 2023 Apr 6;16:71-79. doi: 10.2147/MDER.S397654. eCollection 2023. | |
| 35608314 | Background | Palmer DJ, Robin AL, McCabe CM, Chang DF; Ophthalmic Instrument Cleaning and Sterilization Task Force. Reducing topical drug waste in ophthalmic surgery: multisociety position paper. J Cataract Refract Surg. 2022 Sep 1;48(9):1073-1077. doi: 10.1097/j.jcrs.0000000000000975. |
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| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| Standard Eye Drop Bottle with Proparacaine HCl 0.5% | Combination Product | This intervention involves administration of proparacaine HCl 0.5% using a standard eye drop bottle. |
|
| 24927769 | Background | Moore DB, Walton C, Moeller KL, Slabaugh MA, Mudumbai RC, Chen PP. Prevalence of self-reported early glaucoma eye drop bottle exhaustion and associated risk factors: a patient survey. BMC Ophthalmol. 2014 Jun 13;14:79. doi: 10.1186/1471-2415-14-79. |