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Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experiencing sleep deprivation may experience a decrease in natural killer cells and lymphocytes.
Physicians, particularly those in surgical specialties, are often subjected to sleep deprivation as part of their medical residency training. This study hypothesizes that after 24-hour shifts, there is an increase in inflammatory response and impairment of the immune response against unspecific activation. This proposal aims to provide insight into the impact of sleep deprivation on the immune system of surgery residents by characterizing the phenotype and function of immune cells, as well as their correlation with biometric data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| General Surgery Residents | General Surgery residents on during 24-hour rotation shifts |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood Sample Collection | Diagnostic Test | To characterize the phenotype and function of immune cells in surgery residents before and after a 24-hour shift, and before and after a month of being "on call". Along with to investigate the relationship between sleep deprivation, physical activity, and different immune responses. |
| Measure | Description | Time Frame |
|---|---|---|
| Characterization of the phenotype and function of immune cells using flow cytometry | Specifically, T cells, B cells, dendritic cells, macrophages, and natural killer cells will be identified and analyzed. Memory cells, co-inhibitor markers, and regulatory markers will also be evaluated. The function will be analyzed based on the intracellular expression of effector molecules and cytokines after unspecific activation with CD3-CD28 beads. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Analyze the biometric data and correlate it with changes in sleep deprivation | To examine the associations, participants will be using an activity and sleep monitor. | One week before rotation and the last week of rotation |
| Analyze the biometric data and correlate it with changes in the immune response |
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Inclusion Criteria:
Exclusion Criteria:
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General Surgery residents, on during 24-hour shifts
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Angelica Perez-Gutierrez, MD | Contact | 773-834-5087 | rperezgutierrez@bsd.uchicago.edu | |
| Leila Yazdanbakhsh | Contact | leila.yazdanbakhsh@bsd.uchicago.edu |
| Name | Affiliation | Role |
|---|---|---|
| Angelica Perez-Gutierrez, MD | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Chicago | Recruiting | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Actigraph (GT9X-BT) Monitor | Device | Participants will be asked to wear their monitor every day for a week. The monitor will collect their step count, sleep and heart rate automatically. Participants will return their monitor at visit 5 (day 30) of the study. |
|
To examine the associations, participants will be using an activity and sleep monitor. |
| One week before rotation and the last week of rotation |
| Analyze the biometric data and correlate it with changes in physical activity | To examine the associations, participants will be using an activity and sleep monitor. | One week before rotation and the last week of rotation |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |