Statins, Cholesterol and Cognitive Decline in Alzheimer's

Statins, Cholesterol and Cognitive Decline in Alzheimer's

Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms. The investigators aim to estimate the causal effect of statins on cognitive function measured by MMSE and to identify the mediating or modifying effect of cholesterol between statins and cognitive function in patients with Alzheimer's disease.

Inclusion Criteria:

All patients with AD and mixed dementia registered in SveDem and from SCREAM.

Exclusion Criteria:

• All patients with a missing MMSE score at diagnosis date will be excluded from the analyses.
• Patients with at least one measurement of low-density lipoprotein cholesterol (LDL-C) within 1 year before dementia diagnosis.