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Spinal cord stimulation (SCS) has proven to be effective for pain that is unresponsive to medication. This technique involves an anesthesiologist or a neurosurgeon placing stimulation electrodes at the thoracic vertebrae to provide pain relief. Although SCS is not currently a standard treatment for patients with Parkinson's disease, recent studies have shown that Parkinson's patients who experience intolerable pain and undergo SCS treatment not only experience pain relief but also show improvements in gait and other Parkinson's symptoms. Therefore, the investigators aim to use temporary, minimally invasive SCS electrodes to help patients with nrFOG (non-responsive Freezing of Gait) improve their stability and reduce their risk of falls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SCS implantation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SCS electrode stimulation 1 | Device | 300Hz/300us |
| |
| SCS electrode stimulation 2 |
| Measure | Description | Time Frame |
|---|---|---|
| Gait parameters --- foot rotation [degtree] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- step length [cm] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- stride length [cm] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- step width [cm] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- stance phase [%] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- swing phase [%] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Scale |
| Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Clinical score |
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kai-Hsiang Chen, M.D. | Contact | +886-3-5326151 | 522610 | stanleychen1230@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital Hsin-Chu Branch | Recruiting | Hsinchu | Hsinchu City | 300 | Taiwan |
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| Device |
130Hz/300us |
|
| SCS electrode stimulation 3 | Device | 60Hz/300us |
|
| Gait parameters --- double stance phase [%] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- step time [second] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- stride time [second] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- cadence [steps/minute] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Gait parameters --- velocity [km/hour] | (1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters. | Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Clinical Scale |
| Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Clinical Scale |
| Day 0, Day 2, Day 3, Day 4, and Day 7 |
| Clinical Scale |
| Day 0, Day 2, Day 3, Day 4, and Day 7 |
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
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