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Fatty liver disease, encompassing both alcoholic and non-alcoholic variants, is a growing health concern worldwide, with prevalence rates soaring in parallel with obesity and diabetes epidemics. The estimated global incidence of NAFLD alone is 47 cases per 1,000 people, with a higher rate observed in males than females. Among adults worldwide, the estimated prevalence of NAFLD is 32%, with a higher prevalence in males (40%) compared to females (26%), making it the most common liver disorder. The hazards of fatty liver disease extend beyond the liver itself .The condition is characterized by the accumulation of excess fat in liver cells, which can progress to more severe liver diseases, such as steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Early assessment and diagnosis of liver steatosis are crucial for managing and mitigating the risks associated with FLD. Non-invasive methods, such as elastography combined with the Controlled Attenuation Parameter (CAP) score, have emerged as effective tools for detecting and quantifying liver fat content. These methods offer a less invasive alternative to liver biopsies, providing reliable data to guide clinical decisions.
NAFLD is characterized by a proinflammatory and proatherogenic state that causes vascular inflammation and neurodegeneration, potentially leading to both clinical and subclinical cerebrovascular disease. Increasing epidemiological evidence links NAFLD to a higher risk and greater severity of stroke, independent of other vascular risk factors.Additionally, studies suggest NAFLD is involved in subclinical cerebrovascular diseases, such as carotid atherosclerosis which is characterized by the build-up of plaques in the carotid arteries. Patients with NAFLD exhibited greater carotid atherosclerosis .
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| Measure | Description | Time Frame |
|---|---|---|
| Assess frequency of hepatic steatosis among patients in patients with Ischemic stroke without previous risk factors | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Assess outcomes morbidity and mortality ischemic stroke in correlation with hepatic steatosis . | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Newly diagnosed ischemic cerebral stroke patients exceeding of window phase without obvious risk factors.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mostafa G Gamal | Contact | +20 1147731506 | doctormga610@gmail.com | |
| Noureldine A Abdelazeem | Contact | 01005035180 | noorelhefny@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Mostafa A Gamal | Assiut University | Principal Investigator |
| Noureldine A Abdelazeem | Assiut University | Study Director |
| Bahaa A Osman |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 3201508 | Result | Bonita R, Beaglehole R. Recovery of motor function after stroke. Stroke. 1988 Dec;19(12):1497-500. doi: 10.1161/01.str.19.12.1497. | |
| 10356101 | Result | DeGraba TJ, Hallenbeck JM, Pettigrew KD, Dutka AJ, Kelly BJ. Progression in acute stroke: value of the initial NIH stroke scale score on patient stratification in future trials. Stroke. 1999 Jun;30(6):1208-12. doi: 10.1161/01.str.30.6.1208. |
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| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| Assiut University |
| Study Director |
| 21985544 | Result | Mughal MM, Khan MK, DeMarco JK, Majid A, Shamoun F, Abela GS. Symptomatic and asymptomatic carotid artery plaque. Expert Rev Cardiovasc Ther. 2011 Oct;9(10):1315-30. doi: 10.1586/erc.11.120. |
| 16284135 | Result | Tahmasebpour HR, Buckley AR, Cooperberg PL, Fix CH. Sonographic examination of the carotid arteries. Radiographics. 2005 Nov-Dec;25(6):1561-75. doi: 10.1148/rg.256045013. |