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Acute lung injury is a common complication of subarachnoid hematoma (SAH), and a significant risk factor for death in patients with SAH. Unlike neurogenic pulmonary edema and pneumonia following brain injury, the clinical causes of pulmonary injury after SAH are not intracranial hypertension or pulmonary infection. Its occurrence is influenced by the release of catecholamines, the regulatory function of the hypothalamic-pituitary-adrenal (HPA) axis and systemic inflammatory response, but the specific mechanisms are still unclear. Therefore, delving into the pathological mechanisms of SAH-induced lung injury and developing therapeutic strategies based on the findings is of great importance to improve the prognosis of patients.
Abnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases, such as chest trauma, pulmonary infection and chronic obstructive pulmonary disease. From this, the present research is aimed to explore the levels and dynamic changes of hyaluronic acid in the bronchoalveolar lavage fluid and blood of patients with acute lung injury following SAH, and to analyze its correlation with the prognosis of pulmonary complications, thereby providing assistance for the clinical diagnosis and treatment of SAH.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subarachnoid Hemorrhage (SAH) |
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| Measure | Description | Time Frame |
|---|---|---|
| Hyaluronic acid level in bronchoalveolar lavage fluid after SAH | Hyaluronic acid level (ng/ml) in bronchoalveolar lavage fluid at the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH | During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH |
| Inflammatory cytokines levels in bronchoalveolar lavage fluid after SAH | Inflammatory cytokines (IL-1β, TNF-α and IL-10) levels (pg/ml) in bronchoalveolar lavage fluid at the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH | During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH |
| Measure | Description | Time Frame |
|---|---|---|
| Serum hyaluronic acid level after SAH | Serum hyaluronic acid level (ng/ml) at the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH | During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH |
| Serum inflammatory cytokines levels after SAH |
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Inclusion Criteria:
Exclusion Criteria:
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Estimated by statistical analysis, a total of 24 subjects were included from patients admitted to the neurosurgical intensive care unit of Tianjin Medical University General Hospital and the intensive care unit of Tianjin Huanhu Hospital due to aneurysmal SAH.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xintong Dr. Ge | Contact | 86-13662055012 | xge@tmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Xintong Ge | Tianjin Medical University General Hospital | Study Chair |
| Yadan Li | Tianjin Huanhu Hospital | Principal Investigator |
| Ye Tian |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Medical University General Hospital | Recruiting | Tianjin | 300052 | China |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form: Study Protocol | Sep 30, 2024 | Mar 16, 2026 | Prot_SAP_ICF_001.pdf |
| ICF | No | No | Yes | Informed Consent Form: Informed Consent Form | Sep 30, 2024 | Mar 16, 2026 | ICF_002.pdf |
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| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| D055371 | Acute Lung Injury |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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bronchoalveolar lavage fluid and serum
Serum inflammatory cytokines (IL-1β, TNF-α and IL-10) levels (pg/ml) at the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH |
| During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH |
| Tianjin Medical University General Hospital |
| Principal Investigator |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |