The purpose of this study is to find out how common persistent postmastectomy pain (PPMP) is among people who have had a mastectomy and breast reconstruction surgery for their breast cancer. The study will also look at how effective regenerative peripheral nerve interface (RPNI) surgery is for reducing pain from neuropathic PPMP after breast reconstruction.

Inclusion Criteria:

• Female
• Age ≥18 years
• History of mastectomy for breast cancer or genetic predisposition to breast cancer
• History of breast reconstruction with implants and/or autologous tissue
• At least 6 months of follow-up after reconstruction
• Patient treated at MSK

Exclusion Criteria:

• Exchange or revision surgery within 6 months
• Active medical reason for pain (e.g., infectious, neoplastic, wound related)
• Greater than 15 years post-reconstruction

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.