all cases confirmed diagnosis of Gaucher disease type 3 recieving enzyme replacement therapy at Assiut university hospital

evaluate cardiac involvement in a group of GD type 3 patients, evaluate pulmonary hypertension and valvular involvement, compare the findings of basic echo before the start of replacement therapy as well as with healthy controls, to assess the effects of enzyme replacement therpay on the cardiac function.

Inclusion Criteria:

• Any sex
• No age limit
• Gaucher disease type 3
• Receiving enzyme replacement therapy

Exclusion Criteria:

• Age18 years old
• Cases of gaucher type 1 and 2
• Other lipid storage disease

gaucher diseease type 3