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| Name | Class |
|---|---|
| Pharos University in Alexandria | OTHER |
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The study investigates the effectiveness of the natural product Dandelion in treating obesity in premenopausal women through a randomized interventional trial, measuring various parameters and biomarkers.
The study aims to explore the anti-obesity effects of dandelion supplementation in premenopausal obese women. The research will measure changes in appetite, energy intake, body weight, composition, lipid profile, and inflammatory markers, providing evidence of dandelion's efficacy as an anti-obesity phototherapy. The randomized interventional trial will measure multiple parameters and biomarkers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Active Comparator | The Xenical group:60 patients will receive identical capsules of 120mg (one capsule) to be taken three times daily with meals and for 12 weeks, equaling 360mg total daily dose. |
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| The dandelion extract group | Experimental | The dandelion extract group: 60 patients will receive 500 mg capsules of dandelion leaf extract, given 3 times per day before meals and for 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Xenical | Drug | The Xenical group will receive identical capsules 120mg (one capsule) to be taken three times daily with meals, equaling 360mg total daily dose, which aligns with the usage in adult female patients |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in body weight | monthly change, assessed up to 3 months | |
| Change in fat mass | Monthly change, assessed up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite Ratings | monthly change, assessed up to 3 months | |
| Dietary intake via 24-hour recalls | Recorded for patients daily, assessed up to 3 months | |
| Lipid profile |
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Inclusion Criteria:
Premenopausal women with obesity. Age between 18-45 years Stable body weight in the past 3 months
Exclusion Criteria:
Pregnancy Breastfeeding Diabetes Cardiovascular diseases kidney or liver diseases use of medications that affect body weight Smoking Allergy to dandelion or related plants
Premenopausal Women
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| October 6 University Hospital | Giza | 12566 | Egypt |
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| ID | Term |
|---|---|
| D000077403 | Orlistat |
| ID | Term |
|---|---|
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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| The dandelion extract | Dietary Supplement | The dandelion extract group will receive 500 mg capsules of dandelion leaf extract, given 3 times per day before meals. |
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| Monthly change, assessed up to 3 months |
| CRP | C-reactive protein | Monthly change, assessed up to 3 months |
| TNF-α | Monthly change, assessed up to 3 months |
| IL-6 | Interelukine 6 | Monthly change, assessed up to 3 months |
| IL-16 | Monthly change, assessed up to 3 months |
| Glycemic indices | Monthly change, assessed up to 3 months |