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This clinical trial aims to study the interest of the Pleth Variability Index (PVI) to evaluate perioperative fluid responsiveness in neurosurgery in adults.
The main question it aims to answer is:
• Does the Pleth variability index predict fluid responsiveness in neurosurgery? Researchers will compare the Pleth variability index to dela PP to see if it predicts fluid responsiveness in neurosurgery.
Once participants give their consent, they will be randomly assigned to one of two groups. In one group, fluid responsiveness will be monitored using the Pleth Variability Index, while in the other group, it will be monitored using delta PP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pleth variability index (PVI) | Experimental | Participants will be monitored during the intervention using a Radical-7 Pulse CO-Oximeter to instantly determine the pleth variability index (PVI). If the PVI is more than 14% for at least 5 minutes, 250 ml of gelofusine solution will be given over 10 minutes. |
|
| delta PP | Active Comparator | Participants will be monitored during the intervention using arterial catheter to instantly determine delta PP. If Delta PP is more than 13% for at least 5 minutes, 250 ml of gelofusine solution will be given over 10 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| perioperative fluid responsiveness with the Pleth variability index | Other | Perioperative fluid challenge and responsiveness will be based on monitoring the pleth variability index. In fact, volemia will be estimated with the PVI. |
| Measure | Description | Time Frame |
|---|---|---|
| Value of PVI in fluid responsiveness in neurosurgery | Investigate the value of the plethysmographic variability index (PVI) in assessing the response to perioperative vascular filling in neurosurgery. | chanfe of PVI value from baseline to a value more than 14% and untill the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Amount of fluids administered intraoperatively | during the surgery | |
| Renal, metabolic and hydroelectrolytic repercussions. | up to the first 24 hours postoperatively | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Institute of Neurologie Mongi Ben-Hamida | Tunis | Tunisia |
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| ID | Term |
|---|---|
| D020896 | Hypovolemia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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prospective comparative randomized clinical trial
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| perioperative fluid responsiveness with delta PP | Other | fluid challenge and responsiveness during intervention will be based on monitoring delta PP. |
|
| Length of postoperative stay |
| up to hospital discharge, an average of 4 days |
| Incidence of post-operative complications | up to hospital discharge, an average of 4 days |