The goal of this clinical trial is to learn if intraoperative administration of esketamine would prevent or mitigate postoperative depressive symptoms after cytoreductive surgery in ovarian cancer. The main questions it aims to answer are:

• Whether a single low dose of esketamine administered would reduce the postoperative depressive symptoms three days after cytoreductive surgery in ovarian cancer?
• Whether a single low dose of esketamine administered would relief the postoperative sleep disturbance, postoperative recovery? Researchers will compare the esketamine to a placebo (normal saline) to see if the esketamine works to reduce the postoperative depressive symptoms.

Participants will:

• Receive either 0.2 mg/kg esketamine or placebo infused intravenously after induction of general anesthesia.
• The preoperative Patient Health Questionnaire 9 (PHQ-9) scale was used to verify the symptoms suggestive of depression.

Inclusion Criteria:

• undergoing cytoreductive surgery for ovarian cancer under general anesthesia
• ASA physical status I-III
• Ages 18-80 years

Exclusion Criteria:

• Patients taking anti-psychotic medications
• Contraindications to esketamine
• Language barrier
• Inability to provide consent

We will share data on ClinicalTrials.gov, and data sharing will be always available.

starting about 6 months after publication