Interval Inspiratory Training and Aerobic Exercise for Muscle Recovery in Myasthenia Gravis Post-Hospitalization

Inspiratory Training and Aerobic Exercise for Muscle Recovery in Myasthenia Gravis Post-Hospitalization

The goal of this clinical trial is to determine whether inspiratory muscle training aids in the recovery of respiratory muscle strength and helps prevent further muscle weakness in patients with myasthenia gravis.

The primary research questions are:

Does inspiratory muscle training enhance respiratory muscle strength recovery? Does the intervention lead to improved lung volumes? Participants underwent daily inspiratory muscle training and aerobic exercise for six consecutive weeks.

Patients with myasthenia gravis who experience acute exacerbations requiring hospitalization often suffer a significant decline in muscle strength, followed by partial recovery after the acute phase. This randomized controlled trial aims to evaluate the potential of early inspiratory muscle training and aerobic exercise in promoting muscle strength recovery and preventing further weakness. The study will assess differences in lung function, respiratory muscle strength, and dyspnea levels following the intervention after patients are discharged from the hospital post-acute exacerbation.

Inclusion Criteria:

• Hospitalized due to a myasthenia gravis crisis
• Cleared for discharge from the hospital
• Capable of completing six weeks of home-based respiratory muscle and exercise training

Exclusion Criteria:

• Myasthenia Gravis Foundation of America (MGFA) classification I or V
• Presence of concurrent heart, kidney, liver, or metabolic diseases, or malignant tumors
• Ability to follow exercise instructions
• New York Heart Association (NYHA) Class III/IV
• Pulmonary disease (FEV1/FVC ratio < 0.7 and FEV1 < 50% predicted)