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The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.
Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Excessive iodine group | Residents with thyroid cancer who have lived in high iodine areas for a long time (5 years or more). According to the report of Shandong Institute of Endemic Disease Prevention and Control, three sub centers were selected in Excessive iodine group (Jining/Liaocheng/Heze). |
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| Suitable iodine group | Residents with thyroid cancer who have lived in suitable iodine areas for a long time (5 years or more). According to the report of Shandong Institute of Endemic Disease Prevention and Control, three sub centers were selected in suitable iodine (Jinan/Shenyang/Haerbin) areas. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Iodine excess | Dietary Supplement | Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with recurrence | Recurrence: diagnosed as the same type of thyroid cancer again by pathology | from enrollment to the final follow-up at 5 years |
| Number of participants with distant metastasis | Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland | from enrollment to the final follow-up at 5 years |
| All-cause mortality | The ratio of the total number of deaths caused by various reasons during the research period to the number of participants | from enrollment to the final follow-up at 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions at least for 5 years who was diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qingling Guo | Contact | +86 0531-68776375 | guoqinglingqhb@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shandong Provincial Hospital | Recruiting | Jinan | Shandong | 250021 | China |
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| ID | Term |
|---|---|
| D013964 | Thyroid Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
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| Iodine suitable | Dietary Supplement | Iodine suitable areas：water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L. |
|
| D004700 |
| Endocrine System Diseases |
| D013959 | Thyroid Diseases |