Circulating microRNAs in Small Testicular Masses and Retroperitoneal Post-chemotherapy Residual Masses.

Diagnostic Role of Circulating microRNAs in Small Testicular Masses Suitable for Testis Sparing Surgery and Post-chemotherapy Residual Masses Suitable for Retroperitoneal Lymph Node Dissection.

The purpose of this study is to evaluate the diagnostic performance of circulating microRNAs in detecting the presence of germ cell cancer in patients with small testicular mass or retroperitoneal post-chemotherapy residual mass and suitable for testis sparing surgery and retroperitoneal lymph node dissection, respectively.

COHORT A:

Inclusion Criteria:

• Age >= 18 years
• Single testicular lesion, with < 2 cm diameter and < 30 % testicular volume involvement;
• Negative Serum Tumour Markers;
• Suitable for testis sparing surgery;
• Informed consent.

Exclusion Criteria:

• None

COHORT B:

Inclusion Criteria:

• Age >= 18 years
• Single/multiple post-chemotherapy retroperitoneal lymph node lesion, with > 1 cm (non seminomatous) / > 3 cm (seminomatous) diameter in patients with previous testicular germ cell primary tumour;
• Negative Serum Tumour Markers;
• Suitable for retroperitoneal lymph node dissection;
• Informed consent.

Exclusion Criteria:

• None