Combined Effect of tDCS and Motor or Cognitive Activity in Patients With Alzheimer's Disease

Combined Effect of tDCS and Motor or Cognitive Activity in Patients With Alzheimer's Disease: A Proof-of-Concept Pilot Study

The goal of this clinical trial is to evaluate the effectiveness of combining tDCS with motor or cognitive activities on cognitive functions in patients with AD. Second aim is to investigate if tDCS has a different impact if it is combined with motor or cognitive activities.

Inclusion Criteria:

• Mini Mental State Examination (MMSE) major or equal to 15;
• good level of compliance;
• acetylcholinesterase inhibitor treatment (e.g., donepezil, rivastigmine);
• no modifications of medication during the last four months.

Exclusion Criteria:

• behavioral disorders (e.g., aggressiveness);
• alcohol abuse;
• orthopedic pathology with risk of falls to the ground;
• respiratory pathology;
• severe auditory or visual deficits uncorrected;
• history of epileptic fits;
• anti-epileptic medication;
• metallic body implants; pacemaker;
• psychiatric, neurologic, systemic or metabolic disorders.