circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs [8], are involved in the regulation of various biological functions. They act by sponging off certain microRNAs (miRNAs) and play a role in the pathogenesis of many diseases, including cancers [9-11]. In addition, circRNAs are not com- monly degraded by RNA enzymes present in body flu- ids [8], and most of them possess expression specificity at the tissue, cell, and developmental stage level [12,13]. Thus, they can be ideal clinica

epithelial OC (EOC), the most common form of OC, accounts for 90% of all OC cases [2]. EOC has the highest mortality among all gynecologic tumors and poses a serious threat to women's life [3].herefore, early clinical diagnosis is crucial. Commonly used laboratory indicators for OC diagnosis

Inclusion Criteria:

- patients at South Egypt Cancer institute and Recently diagnosed ovarian cancer patients 2. Patients not went to surgery.

Exclusion Criteria:

• . Patients receive any anti-cancer therapy. 2. Patients diagnosed with other concomitante cancer or chronic disease

apparently healthy group and group of known diagnosed as ovary cancer in assiut uni hospital