This study enrolls adults with primary open angle glaucoma (POAG) who underwent goniotomy intraocular pressure (IOP)-lowering surgery with the C-Rex Instrument. Patients are consented prior to surgery and followed for 12 months postoperatively. Data regarding IOP, use of glaucoma medications, and any device-related complications are collected during the study time period.

This a multicenter, observational real-world evidence study of eligible adults with primary open angle glaucoma (POAG) in whom ab-interno goniotomy surgery with the C-Rex Instrument was performed.

Data is collected from the preoperative visit(s) that directly preceded the surgery, the surgical procedure, and post-surgical visits through 12 months postoperatively.

Specific data collected includes C-Rex Instrument goniotomy surgical details, preoperative and postoperative IOP and use of ocular hypotensive medications, and device-related safety events.

Inclusion Criteria:

• Primary open angle glaucoma
• Goniotomy surgery performed using the C-Rex Instrument

Exclusion Criteria:

• History of intraocular surgery within 8 weeks prior to C-Rex surgery
• Preoperative IOP higher than 33 mmHg
• Presence of a glaucoma type other than POAG
• Presence of clinically significant intraocular pathology other than cataract or glaucoma

Eligible participants who underwent IOP-lowering surgical procedures using the C-Rex Instrument to perform ab-interno goniotomy