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The primary objective is to investigate in stroke patients the impact of geko™ NMES treatment, when used as standard of care for VTE prevention, on brain haemodynamics at different stimulation levels and in three different postural positions (supine, semi-supine [45° seated] and seated). The aim is to identify the optimal stimulation level and postural position for the maximum response (NMES versus no NMES) with regard to relative total haemoglobin concentration (i.e., the sum of relative deoxyhaemoglobin and oxyhaemoglobin concentrations) using fNIRS and EEG.
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| Measure | Description | Time Frame |
|---|---|---|
| Primary outcome | a change in brain haemodynamics (or blood flow) in terms of oxygenated and de-oxygentated blood from baseline to end of study participation. | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary objective | Neurovascular coupling, Cerebral autoregulation and dynamic functional connectivity | 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Adults (over 18 years) with ischaemic stroke more than 7 days from onset
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Countess of Chester Hospital NHS Foundation Trust | Chester | Cheshire | CH2 1UL | United Kingdom | ||
| Countess of Chester Hospital NHS Foundation Trust |
No identifiable patient data will be shared, only the findings of the procedure.
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Chester |
| Cheshire |
| CH4 7PB |
| United Kingdom |
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |