Effect of Inhalational Anesthesia Versus Total Intravenous Anesthesia on Blood Glucose in Type 2 Diabetes Patients

Effect of Inhalational Anesthesia Versus Total Intravenous Anesthesia on Blood Glucose Level in Type 2 Diabetes Mellitus Patients Undergoing Thoracic Surgery : a Comparative Study

The aim of this study is to compare the effect of total intravenous anesthesia (TIVA) and inhalational anesthesia (IHA) as maintenance anesthesia on blood glucose level and complications in type 2 diabetic patients undergoing thoracic surgery . All participants had to understand and give written informed consent , and ethical committee approval (of Faculty of Medicine, Ain Shams University) will be obtained before participants allocation.

• Type of Study: prospective , randomized .

• Study Settings: Ain Shams University hospitals, Cairo, Egypt.

• Study period: 12 months starting from janurary 2024 .

• Study Population: All adult type 2 diabetic patients (30-70 year old) with class II,III based on the American Society of Anesthesiologists (ASA) physical status undergoing elective thoracic surgeries will be randomly assigned into one of the following groups using computer generated codes and opaque sealed envelopes:

  1. Group A will receive total inravenous anesthesia (TIVA).
  2. Group B will receive inhalational anesthesia (IHA)

Inclusion Criteria:

• Age 30 - 70 years
• Sex: Both sexes
• Patients with type 2 diabetes mellitus controlled with oral hypoglycemic drugs
• Patients with ASA classification II,III
• Duration of surgery (≥2 h)

Exclusion Criteria:

• Declining to give written informed consent
• ASA classification Ⅳ to V
• Severe systemic diseases
• Metabolic disorders, diabetic ketoacidosis or hyperglycemia (fasting blood Glucose more than 140 mg/dl)
• Hepatic and/or renal dysfunction
• Neuromuscular disease
• Pancreatic cancer
• History of malignant hyperthermia
• Emergency surgery
• Ischemic heart disease and valvular heart disease
• Body mass index more than 40
• Diabetic patients on insulin therapy