Comparison of Dual-lumen Catheter-guided Mini-forceps Biopsy and Brush Cytology with Vacuum Aspiration in Suspicious Biliary Strictures

Comparison of Dual-lumen Catheter-guided Mini-forceps Biopsy and Brush Cytology with Vacuum Aspiration in Suspicious Biliary Strictures: a Multicenter, Randomized, Crossover Trial

In this randomized crossover trial involving patients with indeterminate biliary strictures, we aimed to compare the diagnostic performance of the dual-lumen catheter-guided miniforceps biopsy (CMB) device with that of brush cytology under aspiration (BCA).

Inclusion Criteria:

• Aged between 18-88 years old.
• Willing and able to comply with the study procedures and provide written informed consent to participate in the study.
• Biliary obstructive symptoms,or indeterminate biliary stricture suspected to be intrinsic based on prior imaging.

Exclusion Criteria:

• Any contraindications to ERCP.
• Severe cardiopulmonary disease or coagulopathy.
• Biliary strictures caused by extrinsic compression.
• Unwillingness or inability to provide consent.
• Pregnant or breastfeeding women.