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Leucocyte subpopulation and platelet indices analysis can predict clinical outcome
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| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and specificity of either leucocyte profiling , platelet indices with early clinical deterioration | SOFA increase 2 points or more, or development of septic shock, or mortality. leukocyte profile versus platelet indices. Early deterioration was defined as any of the above mentioned events occurring for the first time from T0 until (through) second calendar day. T0 was the biomarker sampling immediately after sepsis diagnosis. Timing of deterioration was subclassified from To to second calendar day ( any deterioration events for the first time from T0 until second calendar day after that defined as very early deterioration) or early deterioration ( from third calendar day to day-5 = any deterioration events occur for the first time only from third to the fifth calendar day inclusive after T0 | from biomarker sampling through fifth calendar day |
| Measure | Description | Time Frame |
|---|---|---|
| association between leucocytes at enrollment with ICU mortality | 2 weeks ( during ICU admission) | |
| association between platelet indices at enrollment with ICU mortality | 2 weeks (during ICU admission) |
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Inclusion Criteria:
Exclusion Criteria:
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population admitted to the ICU with a diagnosis of sepsis were screened for inclusion within 48 h of presentation to the hospital. Sepsis was defined as per the Sepsis-3 definition, 6 ie, the presence of suspected or documented infection with organ dysfunction determined by an acute increase of sequential organ failure assessment (SOFA) score by 2 or more points
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mina Maher Raouf | Minya | 61511 | Egypt |
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| association between platelet indices at enrollment with incidence of mechanical ventilation | 2 weeks |
| association between leucocytes at enrollment with incidence of mechanical ventilation | 2 weeks (during ICU admission) |
| association between leucocytes at enrollment , with incidence of acute kidney injury | 2 weeks (during ICU admission) |
| association between platelet indices at enrollment with incidence of acute kidney injury | 2 weeks (during ICU admission ) |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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