The goal of this clinical trial is to learn if inspiratory muscle training facilite the liberation of mechanical ventilation. The main questions it aims to answer are:

Does inspiratory muscle training facilitate weaning from mechanical ventilation and enhance muscle strength in critically ill, subacute adult patients?

The main questions it aims to answer are:

Does pulmonary rehabilitation facilitate wwaning form mechanical patients? Does the intervention improve respiratory muscle strength and respiratory patterns?

Participants received:

Inspriatory muscle training twice daily for three consecutive weeks or until the subject no longer required ventilator support.

Patients on mechanical ventilation often experience rapid diaphragm atrophy on the second day, resulting in muscle fiber changes, respiratory muscle weakness. Clinical studies have explored enhancing diaphragm and respiratory muscle strength and endurance through inspiratory muscle, expiratory muscle, and combined respiratory muscle training. This study was to determine if inspiratory muscle training significantly facilitates liberation from mechanical ventilation and improves muscle strength when compared to without IMT among subacute critically ill adult patients.

Inclusion Criteria:

• requiring invasive mechanical ventilation for 2 days in an ICU

Exclusion Criteria:

• hemodynamic instability (heart rate 120 beats/min, unstable blood pressure, vasopressor infusion)
• inadequate oxygenation (PEEP 8 cmH2O, FiO2 50%)
• body temperature 38.5°C
• sepsis
• use of sedative infusion
• steroid administration
• home ventilator use before ICU admission

The data is available upon request from the principal investigator.

The data will become available 3 three years after the registration

The data is available upon request from the principal investigator.