Deuterium Metabolic Imaging in People with Multiple Sclerosis

Deuterium Metabolic Imaging in People with Multiple Sclerosis

The goal of this case-control study is to investigate glucose brain metabolism in people with multiple sclerosis and age- and sex-matched healthy controls. The main questions it aims to answer are:

• How does brain glucose metabolism in people with multiple sclerosis compare to age- and sex-matched healthy controls?
• How is the brain glucose metabolism of people with multiple sclerosis associated with disease severity?

Participants will come in for testing lasting approximately three hours and undergo deuterium metabolic imaging, physical function test, cognitive function test, and answer survey.

Inclusion Criteria:

• Aged 18-60 years.
• Definite Relapsing remitting multiple sclerosis diagnosis according to the most recent diagnostic criteria

Exclusion Criteria:

• Contraindications for MRI:

Pacemaker, neurostimulator or cholera implant. Metal foreign bodies such as fragments and irremovable piercings. Unsafe medical implants (safety of heart valves, hips and the like must be confirmed).

Claustrophobia. Largest circumference including arms > 160 cm

• Pregnancy
• Competing neurological, psychiatric, or systemic diseases including diabetes (except prior TIA, unspecific brain MRI findings, hypertension, atherosclerosis and hyperlipidemia/cholesterolemia which are allowed).
• Participating in other clinical trials with investigational medical products or drugs.