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Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.
Cheong et al. demonstrated that a simple positive suggestion before ketamine administration could reduce unpleasant dreams, while Kim et al. found that propofol, compared to midazolam, led to more vivid and memorable dreams, along with similar satisfaction levels in patients. This study aims to extend these findings by comparing the effects of propofol and ketamine sedation on dreaming during anesthesia, with a focus on how preoperative suggestions might influence dream content, emotional tone, and patient satisfaction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group with Propofol | Active Comparator | Receives standard preoperative instructions and propofol infusion. |
|
| Suggestion Group with Propofol | Experimental | Receives positive preoperative suggestions and propofol infusion. |
|
| Control Group with Ketamine | Active Comparator | Receives standard preoperative instructions and ketamine infusion. |
|
| Suggestion Group with Ketamine | Experimental | Receives positive preoperative suggestions and ketamine infusion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control Group | Other | Receives standard preoperative instructions and propofol or ketamine infusion. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Dreaming | The "Dreaming and Cognition Evaluation Questionnaire" will be used.questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance. | Dreaming will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU). |
| Quality of Dreaming | The "Dreaming and Cognition Evaluation Questionnaire" will be used. This questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance. | Dreaming will be assessed immediately in the Post-Anesthesia Care Unit (PACU). |
| Measure | Description | Time Frame |
|---|---|---|
| Satisfaction with Care | A 101-point numerical rating scale included in the "Dreaming and Cognition Evaluation Questionnaire" will be used to measure patient satisfaction with the overall care and sedation experience. | Satisfaction will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cheol Lee, M.D.,Ph.D | Wonkwang University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| WonwangUH | Iksan | Please Select | 54538 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41319686 | Derived | Lee D, Lee H, Lee C, Lee C. The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial. Anesth Analg. 2026 Jul 1;143(1):156-162. doi: 10.1213/ANE.0000000000007818. Epub 2025 Nov 24. |
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| ID | Term |
|---|---|
| D017060 | Patient Satisfaction |
| ID | Term |
|---|---|
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| D015742 | Propofol |
| D007649 | Ketamine |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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|
| Suggestion Group | Other | Receives positive preoperative suggestions and propofol or ketamine infusion. |
|
|
| Adverse events |
Any complications such as hypotension,or bradycardia, will be recorded systematically. |
| Monitoring will be continuous with regular vital signs recorded every 5 minutes during surgery and every 15 minutes in the PACU. |
| D008722 | Methods |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |