This study comprises 3 stages:

1. Collection of tumor and blood samples.
2. Creation of organoid models based on tumor samples.
3. Development of functional tests to predict clinical response to treatment.

Inclusion Criteria:

• Patient aged 18 years or more

• Patient with histologically confirmed, localized endometrial cancer, candidate for surgical treatment.

• Patient with localized endometrial cancer, presenting:

  • A high-grade endometrioid histological type and/or
  • P53 mutation and/or
  • a non-endometrioid histological type regardless of P53 status.

• Patient affiliated to a social security scheme

• Information and signature of informed consent prior to any specific study procedure

Exclusion Criteria:

• Other active cancer less than 6 months old (with the exception of treated basal cell carcinoma of the skin).
• Patient deprived of liberty, under guardianship, or subject to a legal protection measure, or unable to express consent.

Patient with localized endometrial cancer