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In France, venous thromboembolism (VTE), which includes pulmonary embolism (PE) and deep-vein thrombosis (DVT), is the 3rd leading cause of cardiovascular disease, leading to major public health problems. Despite current monitoring and treatment, the recurrence rate and the rate of haemorrhagic complications remain high, at 18.5% and 12% respectively in the year following the thrombotic event.
Patients with PE diagnosed in the emergency department are very often admitted to hospital.
However, according to international recommendations on the treatment of PE, outpatient management with early discharge could be envisaged but is rarely carried out in practice, particularly for non-severe PE (spESI = 0).
Current post-pulmonary embolism follow-up involves an early medical consultation with a specialist after discharge from hospital, with follow-up at 1, 3 and 6 months. The aim is to evaluate anticoagulant treatment (high-risk medication), investigate the causes of PE, monitor the patient and decide whether or not to continue anticoagulant treatment 6 months after diagnosis.
Patients diagnosed with non-severe PE can only be monitored as soon as they are discharged from hospital, thanks to an organised and specific care pathway involving healthcare professionals working in towns and cities as well as in hospitals.
In 2018, the French authorities created a new healthcare profession, the advanced practice nurse (APN). They are said to be one of the 'answers' to making care pathways, including PE, even more relevant by improving the quality of patient care and strengthening the town-hospital link.
Thanks to their training and expertise, IPAs can carry out the following activities:
Thus, by intervening at specific times throughout the course of a patient's diagnosis of a non-severe PE, the involvement of the IPA in the patient's follow-up, in addition to current recommendations, would make it possible to reduce the risk of haemorrhagic complications associated with the use of anticoagulants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intensive follow-up | Experimental |
| |
| Routine follow-up | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Routine follow-up | Other | As recommended: a vascular doctor exclusively, face-to-face consultations. |
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of minor and major bleeds | ISTH definition of haemorrhage | Through study completion, on average of 7 months |
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Inclusion Criteria:
Symptomatic PE is confirmed if there is :
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anne-Lise ANTEMI-RIBREUX | Contact | 0380669363 | +33 | anne-lise.antemi@chu-dijon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon Bourgogne | Recruiting | Dijon | 21000 | France |
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| Intensive follow-up | Other | a vascular physician and an IPA, with alternating face-to-face and remote consultations. |
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