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To determine the gene expression of anti-spike IgG through PCR-RT in patients vaccinated with the 4 types of vaccines available in Mexico Oxford/AstraZeneca (ChAdOx1 nCoV-19), Centro Nacional Gamaleya (Sputnik V), Pfizer/BioNTech (BNT162b2) and Sinovac (CoronaVac).
80 subjects with full vaccination schedule will be included, 20 per group To know the gene expression of IgG anti-spike through PCR-RT in patients vaccinated with the 4 types of vaccines available in Mexico Oxford/AstraZeneca (ChAdOx1 nCoV-19), Centro Nacional Gamaleya (Sputnik V), Pfizer/BioNTech (BNT162b2) and Sinovac (CoronaVac).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | 20 persons who have received the Oxford/AstraZeneca vaccine (ChAdOx1 nCoV-19). |
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| Group 2 | 20 persons who have received the vaccine Gamaleya National Center(Sputnik V) |
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| Group 3 | 20 persons who have received the Pfizer/BioNTech vaccine (BNT162b2). |
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| Group 4 | 20 persons who have received the Sinovac (CoronaVac) vaccine. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gene expression mRNA of IgG anti-spike | Other | b) Peripheral venous blood samples (3 ml per occasion) will be taken from all participants. They will be carried out on days 30,60 and 120 after completion of the COVID-19 vaccination schedule. c) Sample processing:
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| Measure | Description | Time Frame |
|---|---|---|
| Immunogenicity induced by COVID-19 vaccines in Mexican population | To characterize the immunogenicity induced by COVID-19 vaccines in Mexican population: mRNA expression for IgG anti-spike. | 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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Mexican men and women over 18 years of age, vaccinated in the last 4 months
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Escuela Superior de Medicina, Instituto Politécnico Nacional | Mexico City | 11340 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32941052 | Result | Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors. Ann Intern Med. 2021 Jan;174(1):69-79. doi: 10.7326/M20-5008. Epub 2020 Sep 17. | |
| 32337143 | Result | Pal M, Berhanu G, Desalegn C, Kandi V. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update. Cureus. 2020 Mar 26;12(3):e7423. doi: 10.7759/cureus.7423. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 10, 2021 | Sep 11, 2024 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jul 10, 2021 | Sep 11, 2024 | ICF_001.pdf |
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| 32418199 | Result | Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, Bolling MC, Dijkstra G, Voors AA, Osterhaus AD, van der Voort PH, Mulder DJ, van Goor H. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol. 2020 Jul;251(3):228-248. doi: 10.1002/path.5471. Epub 2020 Jun 10. |
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| 33102545 | Result | Swelum AA, Shafi ME, Albaqami NM, El-Saadony MT, Elsify A, Abdo M, Taha AE, Abdel-Moneim AE, Al-Gabri NA, Almaiman AA, Saleh Al-Wajeeh A, Tufarelli V, Staffa VN, Abd El-Hack ME. COVID-19 in Human, Animal, and Environment: A Review. Front Vet Sci. 2020 Sep 4;7:578. doi: 10.3389/fvets.2020.00578. eCollection 2020. |
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