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| ID | Type | Description | Link |
|---|---|---|---|
| Chiang Mai University | Other Identifier | Chiang Mai University |
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To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?
Prospective RCT is conducted to compared the amount of fluid volume in adult patients undergoing posterior fossa surgery in park bench position.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pulse pressure variation guidance fluid administration | Experimental | In the PPV group, fluids will be administered to maintain the PPV below 13%. If hypotension coincided with a PPV exceeding 13%, an initial bolus of 200 ml crystalloid fluid solution will be given in10 minutes. PPV reassessment occurred within the subsequent 10 minutes. Alternatively, if hypotension occurs with a PPV measuring less than 13%, vasopressors such as ephedrine at a dose of 3-6 mg or norepinephrine at a dosage of 5-10 mcg intravenously as a bolus, or norepinephrine infusion at a rate of 0.03-0.3 mcg/kg/min, will be given to sustain mean arterial pressure above 65 mmHg. |
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| Central venous pressure guidance fluid administration | Experimental | In the CVP group, intraoperative fluid administration aimed to maintain CVP between 8-12 cmH2O while on mechanical ventilation, ensuring mean arterial pressure remains above 65 mmHg and heart rate within 20% of baseline. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulse pressure variation | Procedure | Fluid administration during posterior fossa surgery in the parkbench position is guided by the PPV value. |
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| Measure | Description | Time Frame |
|---|---|---|
| Total intraoperative fluid administration volumes during surgery | fluid and blood and blood volume transfusion during surgery | during surgery |
| Measure | Description | Time Frame |
|---|---|---|
| vital signs | blood pressure both systolic and diastolic pressure | during surgery, the data will be recorded every 5 minutes throughout the procedure |
| vital signs | blood pressure both systolic and diastolic pressure |
| Measure | Description | Time Frame |
|---|---|---|
| vasopressor requirement | type and amount of vasoactive medication | during surgery and 48 hours at the neurosurgical ICU |
| length of neurosurgical ICU stay | days of ICU stay |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pathomporn P Pin on, Associate Professor | Chiang Mai University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chiang Mai University | Chiang Mai | Chiang Mai | 50200 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40455866 | Derived | Pin On P, Kacha S, Saringkarinkul A, Thanakititham N. Study protocol for a randomized controlled trial comparing pulse pressure variation (PPV) and central venous pressure (CVP) guidance for fluid responsiveness assessment in neurosurgical patients undergoing posterior fossa tumor resection in park bench position. PLoS One. 2025 Jun 2;20(6):e0324590. doi: 10.1371/journal.pone.0324590. eCollection 2025. |
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| ID | Term |
|---|---|
| D015192 | Infratentorial Neoplasms |
| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D002496 | Central Venous Pressure |
| ID | Term |
|---|---|
| D014690 | Venous Pressure |
| D001794 | Blood Pressure |
| D006439 | Hemodynamics |
| D002320 | Cardiovascular Physiological Phenomena |
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Two study groups are parallel according to the block of four randomization.
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Outcome assessor received the anesthetic record form by unknown of the patient and group allocation.
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| Central venous pressure | Procedure | Fluid administration during posterior fossa surgery in the parkbench position is guided by the CVP value. |
|
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| during the admission in neurosurgical ICU up to 3 days after surgery |
| time to extubation | to be able to succesfully extubated, count time period of using ventilator | 48 hours after surgery at the neurosurgical intensive care unit |
| from date of randomization to the day of being discharged from ICU or up to 1 week after surgery, depended on which happen first |
| D009369 | Neoplasms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D002943 |
| Circulatory and Respiratory Physiological Phenomena |