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Diabetic patients, as part of preoperative evaluation, should have glycated hemoglobin (HbA1C) measured. HbA1C provides information on longterm glucose control. There is a suggestion in the literature that elevated A1C levels predict a higher rate of postoperative adverse events, including infections, myocardial infarction, and mortality. It is unclear whether chronic glycemia, as reflected in raised HbA1C level, is the risk factor for adverse perioperative events or whether it is a surrogate measure for poor perioperative glucose management. Conversely, in a retrospective analysis of 431,480 surgeries perioperative glucose was predictive of increased 30-day mortality, but that HbA1C was a less useful predictor of this measure. In our experience of at the University of Alberta Preadmission Clinic there is significant variability with respect to whether diabetic patients have a valid HbA1C measurement i.e. within 3 months of surgery. If a valid measurement is present, there is also considerable variability with respect to diabetes control.
Purpose: The purpose of this study to retrospectively determine the incidence of diabetes in the surgical population and what proportion of diabetic patients have a valid HbA1C. Hypothesis: A valid (measured within 3 months of surgery) HbA1C measurement is frequently missing prior to surgery and when present has a high chance of being higher than normal.
Objectives:
Perform a retrospective analysis of all surgeries in Alberta from November 2019 to the present time looking for the following:
Primary outcomes:
Secondary outcomes:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adults with diabetes having surgery in Alberta since November 2019 | Adults with diabetes having surgery in Alberta since November 2019 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgery | Other | this study in observational study, no intervention. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevelance of diabetes among surgical population | Determine the incidence of diabetes in the surgical population | 11/2019-12/2023 |
| HB1AC measuerment in diabetic patients | Determine the incidence of valid HbA1C in diabetic patients presenting for surgery | 11/2019-12/2023 |
| Long term diabetes control among surgical patients | Determine long-term diabetes control through assessment of HbA1C values in diabetic patients presenting for surgery | 11/2019-12/2023 |
| Measure | Description | Time Frame |
|---|---|---|
| In hospital mortality | Determine association between HbA1C and in hospital mortality | 11/2019-12/2023 |
| Post-operative length of stay | Determine association between HbA1C and post-operative length of stay |
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Inclusion Criteria:
Exclusion Criteria:
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- Adults having any surgical procedure at any hospital in Alberta
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alberta | Edmonton | Alberta | T6G2R3 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16618895 | Background | Dronge AS, Perkal MF, Kancir S, Concato J, Aslan M, Rosenthal RA. Long-term glycemic control and postoperative infectious complications. Arch Surg. 2006 Apr;141(4):375-80; discussion 380. doi: 10.1001/archsurg.141.4.375. | |
| 28746706 | Background | Jones CE, Graham LA, Morris MS, Richman JS, Hollis RH, Wahl TS, Copeland LA, Burns EA, Itani KMF, Hawn MT. Association Between Preoperative Hemoglobin A1c Levels, Postoperative Hyperglycemia, and Readmissions Following Gastrointestinal Surgery. JAMA Surg. 2017 Nov 1;152(11):1031-1038. doi: 10.1001/jamasurg.2017.2350. |
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The study team still debating sharing the IPD
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Feb 21, 2024 | Sep 5, 2024 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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| 11/2019-12/2023 |
| 23636187 | Background | Stryker LS, Abdel MP, Morrey ME, Morrow MM, Kor DJ, Morrey BF. Elevated postoperative blood glucose and preoperative hemoglobin A1C are associated with increased wound complications following total joint arthroplasty. J Bone Joint Surg Am. 2013 May 1;95(9):808-14, S1-2. doi: 10.2106/JBJS.L.00494. |
| 29440113 | Background | van den Boom W, Schroeder RA, Manning MW, Setji TL, Fiestan GO, Dunson DB. Effect of A1C and Glucose on Postoperative Mortality in Noncardiac and Cardiac Surgeries. Diabetes Care. 2018 Apr;41(4):782-788. doi: 10.2337/dc17-2232. Epub 2018 Feb 13. |