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| ID | Type | Description | Link |
|---|---|---|---|
| 1K01DA058152-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate.
We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cold Water | Experimental |
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| Warm Water | Placebo Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water Temperature Variation - WW | Other | Participants are assigned to warm water temperature. |
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| Measure | Description | Time Frame |
|---|---|---|
| Blood Cortisol Levels | Cortisol levels are measured in blood. | Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use |
| Cannabis Used | Grams of product used is calculated. Product is measured before and after use to measure how much was used. | Immediate Post-Use |
| Blood Endocannabinoid Levels | Blood levels of AEA are measured. | Pre-Use/Pre-Water Task, 20 minutes Post-Use |
| Heart Rate | Participant HR is measured via pulse oximeter. | Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use |
| Social Anxiety | Social Interaction Anxiety Scale (SIAS). 20 item survey, questions are answered on scale of 0 (not at all) to 4 (extremely), with higher scores indicating higher social anxiety. Questions are summed, with higher overall scores indicating higher social anxiety. | Pre-Use/Pre-Water Task |
| Inhibitory Control | Go/No-go Task. Participants are asked to complete a cognitive task where they see the text "Go" or "No go" during different trials. When they see "Go", they need to push a button within 2 seconds. When they see "No-go", they need to make sure they do not press the button (for 2 seconds). This is a measure of impulsivity. | Baseline |
| Stress | Stress Subscale of Depression and Anxiety Stress Scale measures stress. On scale from 0 (does not apply to me at all) to 3 (apply to me very much or most of the time). Higher scores indicate higher stress levels. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carillon Skrzynski, PhD | Contact | (734)788-2961 | carillon.skrzynski@colorado.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado at Boulder | Recruiting | Boulder | Colorado | 80309 | United States |
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| Water Temperature Variation - CW |
| Other |
Participants are assigned to cold water temperature and are video recorded. |
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| Pre-Use/Pre-Water Task |
| Blood cannabinoid levels | THC and CBD blood levels are measured. | Pre-Use/Pre-Water Task, 20 minutes Post-Use |
| Current Pain | Internal scale/measure, measured from 0 (no pain) to 10 (worst pain imaginable). Participants report current pain on this self-report scale. | Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use |
| Mood | Profile of Mood States (POMS). Focus on the stress, anxiety, tension, and relaxation questions (combined for a tension/anxiety subscale). Questions are on a scale 1 (not at all) to 5 (extremely). Scores are summed, with higher scores indicating more tension/anxiety. | Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use |