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The purpose of this study was to compare efficacy and side effects of two target delineation methods for stereotactic radiotherapy of metastatic spinal tumors.
The purpose of this study was to compare efficacy and side effects of two target delineation methods for stereotactic radiotherapy of metastatic spinal tumors. This is a bidirectional cohort study planned to enroll approximately 500 patients with metastatic spinal tumors. Patients are divided into two groups according to the target delineation method. Group 1:The target bolume only includes local tumor. Group 2:The target bolume includes local tumor and adjacent vertebral area.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | Group 1(small target delineation):The target bolume only includes local tumor. |
| |
| group 2 | Group 2(small target delineation):The target bolume includes local tumor and adjacent vertebral area. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Target volume delineation | Radiation | Group 1(small target delineation):The target bolume only includes local tumor. Group 2(small target delineation):The target bolume includes local tumor and adjacent vertebral area. |
| Measure | Description | Time Frame |
|---|---|---|
| Disease Control Rate(DCR) | Disease Control Rate(DCR),including complete response(CR),partial response(PR) and stable disease(SD ). | 2 years |
| Pain relief rate | VAS Score(Visual Analog Scale Score) decreased after treatment | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of side effects | radiation myelitis,radiation esophagitis, etc. | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with malignant tumor spinal metastasis who received or will receive stereotactic radiotherapy, without preoperation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hongqing Zhuang, Doctor | Contact | 13051776232 | hongqingzhuang@163.com | |
| Yuxia Wang | Contact | 15001292991 | lily31415926@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Hongqing Zhuang | Peking University Third Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Radiation Oncology Cancer Center, Peking University Third Hospital 49# North Garden Rd.,Haidian Dist. | Recruiting | Beijing | Beijing Municipality | 100191 | China |
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| ID | Term |
|---|---|
| D013120 | Spinal Cord Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| D013118 |
| Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |