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| ID | Type | Description | Link |
|---|---|---|---|
| MK-1026-007 | Other Identifier | MSD |
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The goal of the study is to measure and compare the levels of nemtabrutinib in the blood after taking different forms of nemtabrutinib orally on an empty stomach (fasted) to see if they are the same or different.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nemtabrutinib Form A | Experimental | Participants receive nemtabrutinib form A orally. |
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| Nemtabrutinib Form B | Experimental | Participants receive nemtabrutinib form B orally. |
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| Nemtabrutinib Form C | Experimental | Participants receive nemtabrutinib form C orally. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nemtabrutinib | Drug | Oral administration |
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| Measure | Description | Time Frame |
|---|---|---|
| Parts 1 and 2: Area Under the Concentration-Time Curve from Time 0 to Infinity (AUC0-Inf) of Nemtabrutinib | Blood samples will be collected to determine the AUC0-inf of nemtabrutinib. | At designated time points (up to approximately 2 weeks) |
| Parts 1 and 2: Maximum Plasma Concentration (Cmax) of Nemtabrutinib | Blood samples will be collected to determine the Cmax of nemtabrutinib. | At designated time points (up to approximately 2 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants Who Experience an Adverse Event (AE) | An AE is any untoward medical occurrence in a participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. The number of participants who experience an AE will be reported. | Up to approximately 2 months |
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Inclusion Criteria:
The key inclusion criteria include but are not limited to the following:
Exclusion Criteria:
The key exclusion criteria include but are not limited to the following:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Director | Merck Sharp & Dohme LLC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| QPS-MRA, LLC-Early Phase (Site 0002) | South Miami | Florida | 33143 | United States |
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| Label | URL |
|---|---|
| Merck Clinical Trials Information | View source |
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| ID | Term |
|---|---|
| D019337 | Hematologic Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| C000721068 | ARQ531 |
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| Number of Participants Who Discontinue Study Due to an AE |
An AE is any untoward medical occurrence in a participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. The number of participants who discontinue study due to an AE will be reported. |
| Up to approximately 2 months |