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To find the relation of Helicobacter pylori with disease activity in SLE and RA
H. pylori is a widespread, spiral-shaped, flagellated Gram-negative bacterium usually infects the gastric mucosa.Its seropositivity increases with age as it affects about eighty percent of the middle-aged adults in the developing countries and about twenty-five to fifty percent in the western populations.The relation between infection and autoimmune diseases has been previously investigated. Many Gram-negative bacteria as salmonella, shigella, and chlamydia were confirmed to be associated with the development of reactive arthritis.These bacteria have been found to stimulate the host immune response due to the presence of lipopolysaccharides and other antigenic molecules that can cause inflammation.It has been previously hypothesized that H. pylori can induce such immune host response through many mechanisms as the molecular mimicry and antigenic similarity, disruption of the tolerogenic immune response, and activation of the polyclonal lymphocytes leading ultimately to the imbalance between T regulatory/Th17 cells in addition to the induction of autoantibody production
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 (SLE group): | 50 patients fulfilling the1997 revised American Collage of Rheumatology classification criteria for SLE according to (Hochberg, 1997)., and h_pylori positive |
| |
| Group 2 (RA group): | 50 RA patients diagnosed according to the American college of rheumatology (ACR)-EULAR RA classification criteria 2010. And H_pylori positive |
| |
| Group 3 | 50 heqlthy age and sex matched adults were selected as control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Full history , clinical examination, assesment of disease activity ,Laboratory investigations ( CBC , ESR, CRP Serum creatinine and blood urea, Random plas | Other | 2. Complete clinical examination 3. Assessment of disease activity The following disease activity parameters were used to assess the current activity of each disease:
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of activity of SLE and RA after treatment of H Pylori infection | Prevalence of activity of SLE and RA after treatment of H Pylori infection | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patient of RA and SLE above the age of 18 yrs Presented with hyplori infection
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fatma Mostafa Mohamed Ahmed | Contact | 01004313003 | Fatmamostf32@gmail.com | |
| Husseian Ahmed Elamin | Contact | 01004084187 | elamin67@yahoo.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12839 | Background | Fontes M. Purification and properties of acid phosphatases isolated from Owenia fusiformis. Biochimie. 1976;58(10):1155-8. doi: 10.1016/s0300-9084(76)80113-7. | |
| 115691 | Background | Hahn P, Vikterlof KJ, Rydman H, Beckman KW, Blom O. The value of whole body bone scan in the pre-operative assessment in carcinoma of the breast. Eur J Nucl Med. 1979 Jun 1;4(3):207-10. doi: 10.1007/BF00620487. |
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| 3964 | Background | Zanchetti A, Stella A, Leonetti G, Morganti A, Terzoli L. Control of renin release: a review of experimental evidence and clinical implications. Am J Cardiol. 1976 Mar 31;37(4):675-91. doi: 10.1016/0002-9149(76)90413-6. |
| ID | Term |
|---|---|
| D012149 | Restraint, Physical |
| D001772 | Blood Cell Count |
| D001806 | Blood Urea Nitrogen |
| D005773 | Gastroscopy |
| ID | Term |
|---|---|
| D032763 | Behavior Control |
| D013812 | Therapeutics |
| D007103 | Immobilization |
| D008919 | Investigative Techniques |
| D002452 | Cell Count |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006403 | Hematologic Tests |
| D002468 | Cell Physiological Phenomena |
| D001790 | Blood Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D007677 | Kidney Function Tests |
| D003950 | Diagnostic Techniques, Urological |
| D016099 | Endoscopy, Gastrointestinal |
| D016145 | Endoscopy, Digestive System |
| D003938 | Diagnostic Techniques, Digestive System |
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019060 | Minimally Invasive Surgical Procedures |
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