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Fluid resuscitation is one of the cornerstones of treatment in ICU patients. Nonetheless, excessive fluid administration can lead to fluid overload which has been associated with worse outcomes in the ICU. To prevent this, assessments of fluid responsiveness are commonly employed. However, fluid responsiveness does not take fluid tolerance into account. Fluid tolerance is the idea that a patient might still be fluid responsive but might already be at risk of the detrimental effects of fluid therapy. Recent developments in point of care ultrasound e.g. the Venous excess ultrasound might help identify patients at risk of fluid overload. However its association with patient relevant outcomes in the ICU remains unclear.
This study will investigate the association between the venous excess ultrasound grading system (VExUS) and patient relevant outcomes such as acute kidney injury, mortality and length of stay.
A secondary analysis is planned where the association between VExUS and the lung ultrasound score will be investigated
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| Measure | Description | Time Frame |
|---|---|---|
| Rate of acute kidney injury | Clinically relevant acute kidney injury in the ICU: a 200% rise in creatinine or the use of renal replacement therapy | within 30 days of admission to the ICU |
| Mortality | death of all causes | within 30 days of admission to the ICU |
| Rate of MAKE-30 | a composite endpoint of mortality and acute kidney injury ( including renal replacement therapy) | within 30 days of admission to the ICU |
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| Measure | Description | Time Frame |
|---|---|---|
| Lung ultrasound score | a score for lung aeration as assessed by ultrasound ranging from 0 to 36 where 0 is the normal physiological state | maximum of 3 times during the first 7 days of admission |
| Cardiac function as assed by ultrasound |
Inclusion Criteria:
Exclusion Criteria:
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All cricitally ill patients who are expected to be admitted to the ICU for more than 24 hours and who do not meet the exclusion criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pieter R Tuinman, PhD | Contact | 0204444444 | p.tuinman@amsterdamumc.nl | |
| P Klompmaker, MSc | Contact | 0204444444 | p.klompmaker@amsterdamumc.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Amsterdam UMC | Recruiting | Amsterdam | North Holland | 1081HV | Netherlands |
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| ID | Term |
|---|---|
| D004487 | Edema |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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determined by eyeballing and measurement of the tricuspid annular plane systolic excursion (>16 is normal)
| maximum of 3 times during the first 7 days of admission |