The Effect of Anti-inflammatory Cryoagent on the Level of... | NCT06584188

Status Module

Description Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Intra-radicular saline at room temperature	Experimental	Final flush with 20 mL of saline solution At room temperature for 5 minutes. Three samples will be collected from periapical fluid .	Drug: anti-inflammatory ketorolac tromethamine

Interventions

Name	Type	Description	Arm Group Labels	Other Names
anti-inflammatory ketorolac tromethamine	Drug	Intra- radicular anti-inflammatory {ketorolac tromethamine at room temperature}. Intra- radicular cold anti-inflammatory {ketorolac tromethamine at 2-5C}.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Level of pre-operative pain.	measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)	before start the operative
Level of Post-operative pain.	measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)	6 hours post operative
Level of Post-operative pain.	measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)	24 hours post operative
Level of Post-operative pain.	measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)	48 hours post operative
Level of Post-operative pain.	measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)

Secondary Outcomes

Measure	Description	Time Frame
Level of substance P expression.	Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.	15 minutes following access cavity preparation.
Level of substance P expression.

Eligibility Module

ID	Term
D011183	Postoperative Complications
D010335	Pathologic Processes
D013568	Pathological Conditions, Signs and Symptoms
D010146	Pain
D009461	Neurologic Manifestations
D012816	Signs and Symptoms