This study focuses on the structure and function of the brain and gene expression in peripheral blood of patients with schizophrenia, to explore the interaction and influence between the three. Patients with mental disorders who have been recruited will take their medication regularly for 1 year and participate in baseline and follow-up assessments.

The study seeks to identify possible biological markers of schizophrenia and the effects of gene-environment interactions on brain structural and functional networks. So we can help doctors and scientific researchers better understand the neuropathological basis of schizophrenia.

Inclusion Criteria:

• Age: 13-35 years old(Patients with healthy siblings can be extended to 14-35 years of age)
• Course of disease: <24 months
• Priority is given to patients who have never taken medicine or duration of drug use < 2 weeks
• No nuclear magnetic contraindications.

Exclusion Criteria:

• Family history of psychotic disorders, history of psychoactive substances abuse, alcohol dependence, or nicotine dependence
• Have a major physical disease or infectious disease
• History of coma and serious neurological disease 4.MRI contraindications.

Patients from inpatient and outpatient the second Xiangya Hosptial of Central South University, Healthy controls from community, school and street recruitment