Effectiveness of an Adapted Physical Activity Program for Subjects Suffering From Haemophilia

Effectiveness of an Adapted Physical Activity Program for Subjects Suffering From Haemophilia:a Prospective Interventional Study

The present study aims to evaluate the modification of functional capacity induced by an adapted physical activity program in subjects with haemophilia.

The exercise program used aims to improve joint mobility, muscle strength, static and dynamic balance, motor coordination.

The program is structured in 1 hour sessions of 2 days/week and lasts 6 months.

The primary endpoint is the change in functional capacity calculated as the difference between the baseline assessment and the 3 and 6 month assessment of the 6 Minutes Walking Test measured with the G-Walk (BTS Bioengineering S.p.A).

Inclusion Criteria:

• Diagnosis of hemophilia A or B;
• Signature of informed consent;
• Availability of a medical certificate for non-competitive activities

Exclusion Criteria:

• Active bleeding
• Severe joint deformities that prevent exercise
• Insufficiency of communicative and/or sensory functions so severe that it is impossible to understand or carry out the trainer's instructions (dementia, aphasia, blindness, deafness)
• Heart failure (NYHA class > 2)
• Unstable angina
• Lung disease requiring oxygen therapy
• Symptomatic peripheral arterial disease
• Myocardial infarction or hospitalization within the previous 6 months
• Symptomatic orthostatic hypotension
• Hypertension in poor pharmacological control (diastolic> 95 mmHg, systolic> 160 mmHg)
• Significant neurological conditions that impair motor or cognitive function