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TRacking Atopic dermatitis Infants and their Microbiome: A study to primarily assess the user experience of parents of infants with early onset eczema and parents of healthy infants on OneBiome real-world evidence research platform.
Parents of healthy infants as well as parents of infants with early onset eczema:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Infants | Healthy. no atopic dermatitis | ||
| Infants with early onset of eczema | diagnosed with early onset eczema |
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| Measure | Description | Time Frame |
|---|---|---|
| user experience using a survey form to evaluate user's understanding of OneBiome report | user experience of reading and understanding the microbiome and eating pattern analysis reports. | Up to age 18 months |
| user experience using a survey form to evaluate user's perspective on using OneBiome report to monitor microbiome and eating pattern | User experience of using and understanding the microbiome and nutrition platforms that allow parents to monitor microbiome and eating patterns of their child overtime. | Up to age 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| HCP reported applicability of OneBiome concept by parents via a survey form | HCP reported applicability of microbiome/eating pattern profiles of their patients for their general practice, and to assess parents' overall feedback on OneBiome concept. | Up to age 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Association between microbiome composition, eczema conditions and known factors that influence the microbiome in early life | To investigate association between microbiome composition, eczema conditions and known factors that influence the microbiome in early life including mode of delivery, antibiotic prophylaxis, infant feeding patterns and diet. | Up to age 18 months |
Inclusion Criteria:
Exclusion Criteria:
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Infants with early onset eczema (n=30, <12 months of age) and healthy infants (n=30, <6 months of age).
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| Name | Affiliation | Role |
|---|---|---|
| Bee Wah Lee, MBBS | The Child and Allergy Clinic - Mount Elizabeth Hospital | Principal Investigator |
| Wen Chin Chiang, MBBS | Chiang's Children Allergy and Asthma Clinic - Mount Elizabeth Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mount Elizabeth Hospital | Singapore | 228510 | Singapore |
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
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Stool sample
| Association between microbiome composition, dietary/eating patterns, and gut health parameters | To determine any association between microbiome composition, dietary/eating patterns, and gut health parameters (stool consistency, frequency, colour, constipation, gastrointestinal infection, antibiotic intake) including stool images. | Up to age 18 months |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |