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| Name | Class |
|---|---|
| Anastasios Mpontozis | UNKNOWN |
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60 patients ASA I-III, undergoing total hip arthroplasty were randomly assigned, into one of two groups, namely group E (n=30), where levobupivacaine will be administeral intrathecally ; and group N (n=30), where levobupivacaine plus nalbuphine will be administeral intrathecally. All patients will receive a standardized multimodal analgesic regimen, including a PENG block and PCA morphine. Morphine consumption during the first 24 hours postoperatively will be measured and additionally the investigators will record: Time of morphine first dose administration, NRS scores in static and dynamic conditions in 4 hours, 6 hours, 12 hours, 18 hours, 24 hours, 36 hours and 48 hours postoperatively, complications, patient satisfaction and duration of hospitalization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| E | Active Comparator | Spinal levobupivacaine |
|
| N | Active Comparator | Spinal levobupivacaine plus nalbuphine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levobupivacaine | Drug | Regional anesthesia / analgesia |
| |
| Levobupivacaine plus nalbuphine |
| Measure | Description | Time Frame |
|---|---|---|
| Morphine consumption | 24 hours | |
| NRS scores | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| sensory block level | 1 hour | |
| motor block level | 1 hour | |
| sensory block onset |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asklepieion Hospital of Voula | Athens | Ελλάδα (+30) | 16675 | Greece |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000077554 | Levobupivacaine |
| D009266 | Nalbuphine |
| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| Drug |
Regional anesthesia / analgesia |
|
| 1 hour |
| motor block onset | 1 hour |
| sensory block duration | 4 hours |
| motor block duration | 4 hours |
| Complications | 24 hours |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Aniline Compounds |
| D000588 | Amines |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |