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The investigators aimed to evaluate the efficacy and safety of new HA filler for nasolabial fold correction
A 24-week prospective, single-center, assessor-blinded, randomized, split-face study was conducted to compare the clinical efficacy and safety of new HA filler versus Juvederm for nasolabial fold correction
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| New HA filler (Curea) | Experimental | The left/right assignment was sealed in a nontransparent envelop. |
|
| Juvederm | Active Comparator | The left/right assignment was sealed in a nontransparent envelop. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CUREAⓇ (ARIBIO, Ltd., Seoul, Republic of Korea) | Drug | Hyaluronic acid filler injection were administered into the mid-dermis of the nasolabial fold. |
|
| Measure | Description | Time Frame |
|---|---|---|
| WSRS | Wrinkle Severity Rating Scale from 1 (no visible fold) to 5 (extremely deep and long folds) | at 24 weeks after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| GAIS | Global Aesthetic Improvement Scale from 3 (very much improved) to -1 (worse). | at 24 weeks after treatment |
| Adverse events related to the procedure | Patients were required to report any adverse events up to 24 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bo Ri Kim, M.D., Ph.D. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40707029 | Derived | Kim BR, Shin JW, Kim DW, Choung JJ, Jang Y, Lee SH, Seo BS, Huh CH. Efficacy and Safety of New Hyaluronic Acid Filler for Nasolabial Fold Correction: A Double-Blind, Randomized Trial. Plast Reconstr Surg. 2026 Feb 1;157(2):249-256. doi: 10.1097/PRS.0000000000012320. Epub 2025 Jul 21. |
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| ID | Term |
|---|---|
| D036881 | Long-Term Synaptic Depression |
| ID | Term |
|---|---|
| D009473 | Neuronal Plasticity |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| JuvedermⓇ (Q-Med AB, Uppsala, Sweden) | Drug | Hyaluronic acid filler injection were administered into the mid-dermis of the nasolabial fold. |
|
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| up to 24 weeks |