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Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis
Acronym: Expansion:
HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Persistant hypophosphatasemia |
| ||
| Transient hypophosphatasemia (Control group without hypophosphatasia) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Second alkaline phosphatase measurement | Diagnostic Test | (1-4 weeks after the 1st measurement) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of hypophosphatasia in adult patients in rheumatology | The primary aim of this prospective observational study is to determine the prevalence of hypophosphatasia in adult patients presenting with musculoskeletal symptoms in rheumatology. | 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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Any adult patient presenting at the participating study site's rheumatology department with musculoskeletal complaints within the timeframe of the study conduct.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Valentin S. Schäfer, Univ.-Prof. Dr. med. MUDr. | Contact | +49 228 287-17000 | rheumatologie@ukbonn.de | |
| Claus-Jürgen Bauer, MD | Contact | +49 228 287-17000 | rheumatologie@ukbonn.de |
| Name | Affiliation | Role |
|---|---|---|
| Valentin S. Schäfer, Univ.-Prof. Dr. med. MUDr. | University Hospital of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn | Recruiting | Bonn | North Rhine-Westphali | 53127 | Germany |
Data will be available upon reasonable request
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|
| ID | Term |
|---|---|
| D007014 | Hypophosphatasia |
| D030342 | Genetic Diseases, Inborn |
| D035583 | Rare Diseases |
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D008664 | Metal Metabolism, Inborn Errors |
| D008661 | Metabolism, Inborn Errors |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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