Objectives of the study are:

• The validation of the GMAS questionnaire in patients with chronic disease.
• Measurement of the level of therapeutic adherence in patients with chronic illness.
• Measurement of the level of therapeutic adherence in patients with chronic disease undergoing an experimental trial.

The research is multicentre and will be conducted at the Fondazione Policlinico Gemelli IRCCS in Rome as reference centre together with the other participating centres. Patients will be enrolled at the centres involved, either during visits or during their hospital stay.

Inclusion Criteria:

• Chronically ill;
• Age 18 years or older;
• Willingness to participate in the study;
• Chronic illness diagnosed at least 3 months before the start of the study;
• Reading and signing the informed consent.

Exclusion Criteria:

• Reduced command of the Italian language;
• Subjects suffering from severe psychiatric disorders;
• Serious clinical conditions that do not permit completion of the questionnaire;
• Refusal to sign the informed consent to participate in the study.

Patients with chronic diseases