To verify whether unrestricted access to flavored products is likely to lead to greater reductions in combustible cigarette smoking and decreased exposure to smoking related toxicants.

US adult smokers will be randomized into three groups (Group I: (control) continue smoking their usual brand of CC; Group II: provided with tobacco flavor and unflavored options of ZYN; Group III: provide with unrestricted flavor options of ZYN) to evaluate the impact of availability of different ZYN products on cigarette usage patterns and biomarkers of exposure over a 12-week study period, followed by an 6-week extension for some participants.

Inclusion Criteria:

• Healthy adult smokers 22 to 65 years of age (inclusive) at screening.
• Smokes an average of at least 10 commercially available cigarettes per day for the last 12 months.
• Interested in switching from combustible cigarettes to nicotine pouch products.

Exclusion Criteria:

• Participants of childbearing potential (CBP) who are breast-feeding or have a positive pregnancy test.
• Participants who currently use nicotine pouches.
• Participants with known heart disease or medical condition that may adversely affect participant safety