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The goal of this clinical trial is to discuss the effects of physical activity on nutrition, inflammation, muscle metabolism, and the occurrence of cardiovascular and cerebrovascular events in patients with maintenance haemodialysis. The main question it aims to answer is: can exercise improve nutritional and inflammatory status, enhance muscle strength, and reduce the incidence of cardiovascular and cerebrovascular events in patients with maintenance haemodialysis.
Researchers will compared active exercise group to conventional treatment group to see the impact of exercise on maintenance haemodialysis patients.
Participants will:
Choose low-intensity aerobic exercise workouts such as walking (no less than 8,000 steps per day) or jogging, swimming, Tai Chi, etc., according to their individual conditions, for no less than 30 minutes at a time, at least 3 times per week, and the intensity of the exercise should be based on an RPE score of 12 to 16.
RPE: Rating of Perceived Exertion. RPE scores of 12 to 16 indicate the need for increased respiratory rate and depth during exercise, the ability to engage in conversational exchanges, light sweating, and a feeling of slight fatigue without reaching a state of exhaustion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| exercise group | Experimental | patients were asked to choose walking (no less than 8000 steps per day) or low-intensity aerobic exercise such as jogging, swimming, Tai Chi, etc., according to their own conditions, for no less than 30 minutes each time, at least 3 times per week, and the intensity of the exercise was determined by the need to increase the frequency and depth of breathing during the exercise, and it was appropriate to feel slightly tired but not exhausted (RPE score 12-16). Exercise intensity should be at least 3 times a week, and the exercise intensity should be at a level that requires an increase in breathing rate and depth, allowing for dialogue and communication, slight sweating, and a feeling of being slightly tired but not exhausted (RPE score of 12 to 16). |
|
| Control group | No Intervention | only receive conventional MHD treatment, no requirement for exercise. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise | Behavioral | such as walking, jogging, swimming, Tai Chi, etc. It needs to be at a certain frequency and intensity |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mid-upper arm circumference of the non-internal fistula side（AC） | Measure the circumference of the non-internal fistula at the midpoint of the upper arm using a soft tape measure, in centimetres | Baseline and half year, 1 year |
| triceps skin-fold thickness of the non-internal fistula side（TSF） | Measurement of the skinfold at the midpoint of the upper arm on the non-internal fistula side by using a skinfold thickness gauge, in centimetres | Baseline and half year, 1 year |
| upper arm muscle circumference of the non-internal fistula side（AMC） | AMC（cm）= AC(cm) - 3.14 x TSF（cm） | Baseline and half year, 1 year |
| calf circumference | Measure the calf circumference using a soft tape measure, in centimetres | Baseline and half year, 1 year |
| grip strength | Using a grip strength meter, with the patient seated and gripping the handle firmly with the palm of the non-internal fistulae side, measure twice and record the maximum grip strength value | Baseline and half year, 1 year |
| Incidence of cardiovascular and cerebrovascular events | Cardiovascular events include: heart failure episodes, sustained arrhythmias, myocardial infarction, and cerebrovascular events include: cerebral haemorrhage, cerebral infarction, transient ischaemic attack. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| prealbumin | laboratory measurement indicators:prealbumin(g/L) | Baseline and half year, 1 year |
| albumin | laboratory measurement indicators:albumin(g/L) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Chongqing Medical University | Recruiting | Chongqing | Chongqing Municipality | 400016 | China |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D007249 | Inflammation |
| D009133 | Muscular Atrophy |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020879 | Neuromuscular Manifestations |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Active exercise group: patients were asked to choose walking (no less than 8000 steps per day) or low-intensity aerobic exercise such as jogging, swimming, Tai Chi, etc., according to their own conditions, for no less than 30 minutes each time, at least 3 times per week, and the intensity of the exercise was determined by the need to increase the frequency and depth of breathing during the exercise, and it was appropriate to feel slightly tired but not exhausted (RPE score 12-16).
Exercise intensity should be at least 3 times a week, and the exercise intensity should be at a level that requires an increase in breathing rate and depth, allowing for dialogue and communication, slight sweating, and a feeling of being slightly tired but not exhausted (RPE score of 12 to 16).
Control group: only receive conventional MHD treatment, no requirement for exercise.
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| Baseline and half year, 1 year |
| haemoglobin | laboratory measurement indicators:haemoglobin(g/L) | Baseline and half year, 1 year |
| blood lipids | laboratory measurement indicators:triglycerides, cholesterol, low-density lipoprotein, high-density lipoprotein | Baseline and half year, 1 year |
| c-reactive protein | laboratory measurement indicators:c-reactive protein(mg/L) | Baseline and half year, 1 year |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D012816 | Signs and Symptoms |