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The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties. This present study aims to explore the effects of colchicine on platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy.
Recent landmark clinical trials on the use of colchicine in patients with chronic coronary artery disease has led to its implementation as an FDA approved drug for secondary prevention in patients with coronary artery disease. Colchicine exerts a range of anti inflammatory effects which plays a major role in reduction of atherosclerosis and prevention cardiovascular events. This current study aims to investigate the effect of colchicine on platelet reactivity in patients with stable coronary artery disease already on dual anticoagulants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Colchicine 0.5mg po bd | Experimental | Patients with coronary disease taking Colchicine 0.5mg twice-daily orally for two weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Colchicine 0.5 MG oral tablet twice daily | Drug | Blood samples will be collected from participants in 2 separate instances. Initially, a baseline VerifyNow P2Y12 PRU and Aspirin reaction unit test assay, followed by a subsequent repeat test 2-week after a 2-week, colchicine 0.5mg oral tablet twice-daily |
| Measure | Description | Time Frame |
|---|---|---|
| P2Y12 reaction units and Aspirin reaction units | P2Y12 and Aspirin reaction units pre and post colchicine 0.5mg twice daily oral dose. | two weeks |
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Inclusion Criteria:
Exclusion Criteria:
• Patients already on colchicine
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| Name | Affiliation | Role |
|---|---|---|
| Naveen Seecheran | The University of The west Indies, Saint Augustine, Trinidad and Tobago. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of The West Indies | Saint Augustine | Trinidad and Tobago |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39826082 | Derived | Seecheran N, Grimaldos K, McCallum P, Ramcharan P, Kawall J, Katwaroo A, Grimaldos G, Seecheran V, Jagdeo CL, Rafeeq S, Seecheran R, Leyva Quert A, Ali N, Peram L, Motilal S, Ramtahal R, Bhagwandass N, Giddings S, Ramlackhansingh A, Sandy S. The Effect of Colchicine on Platelet Function Profiles in Patients with Stable Coronary Artery Disease: The ECLIPSE Pilot Study. Cardiol Ther. 2025 Mar;14(1):87-100. doi: 10.1007/s40119-024-00393-2. Epub 2025 Jan 18. |
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The data that support the findings of this study are available from the corresponding author on request.
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D003078 | Colchicine |
| ID | Term |
|---|---|
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
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|
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |