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Peripheral nerve blocks are routinely used and highly successful for intra-operative anesthesia and post-operative pain management. Nerve blocks are guided using either neurostimulation as a means to localize the right nerve or by ultrasound guidance or combining the 2 methods. The purpose of this study is to assess whether electrical stimulation improves nerve block quality, beyond its simple purpose of nerve localization.
The investigators wish to understand how electrical stimulation can affect local anesthetic disposition when performing a peripheral nerve block.
By studying this subject, the investigators open possibilities for improvement on many levels:
increasing the efficacy of the nerve block allows for a reduced onset time, reduced incidence of incomplete block and prolonged duration of the local anesthetics. This allows for patients to fully benefit from the analgesic properties of the nerve block, allows for a decrease in delays for the operating room readiness, and a decrease in the amount of medication needed for a successful nerve block. This will decrease side effects and risks of the nerve blocks. Overall better post-surgical pain control may decrease risks for developing chronic post-operative pain, a major post-operative complication.
The results of this study will open the door to novel approaches to manage acute post-operative pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ultrasound-guided brachial plexus block with peripheral nerve stimulation | Experimental | Patients will receive a brachial plexus catheter with ultrasound guidance as per standard of care, with additional use of the B. Braun HNS 12 nerve stimulator during the loading dose of local anesthesia to maintain a gentle twitch. |
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| Ultrasound-guided brachial plexus block without peripheral nerve stimulation | Sham Comparator | Patients will receive the brachial plexus catheter in the same way the first arm would, and the B Braun nerve stimulator will be placed in the same way, but the ground electrode will not be connected to the patient. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| B Braun HNS 12 nerve stimulator | Device | Nerve stimulator that is traditionally used for nerve localization during block placements. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Onset of sensory block | Determining time when patient experience first symptoms of local anesthetic action on the upper trunk distribution (median or musculo cutaneous nerve) | Within 1 hour after the block placement |
| Measure | Description | Time Frame |
|---|---|---|
| Onset of motor block | Determining time when patient start loosing strength at the musculo cutaneous nerve (biceps brichialis muscle) | Within 1 hour after the block placement |
| Duration of sensory block |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University Hospital | Stanford | California | 94305 | United States |
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| ID | Term |
|---|---|
| D013001 | Somatoform Disorders |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| B Braun HNS 12 nerve stimulator sham control | Device | Stimulator will be placed and turned on, but the grounding electrode will not be connected to prevent nerve stimulation. |
|
Time after surgery at which the patient recovers first sign of sensory function
| up to 7 days after surgery |
| duration of motor block | Time after surgery at which the patient recovers a biceps brachialis function | up to 7 days after surgery |
| When patient experience first pain | Time after surgery at which the patient experience first sign of pain at the surgical site | up to day 7 post operatively |
| Time of first opioid taken | When the first opioid was taken | within the first 7 days after surgery |
| Opioid usage at day 1 | Milligram of morphine equivalent | at post operative day 1 |
| opioid usage assessment at day 7 | Milligram of morphine equivalent taken | Within the Post operative day 1 and 7 |
| Opioid usage assessment at day 28 | milligram of morphine equivalent assess at day 28 | usage between post operative day 7 and 28 |
| Last opioid usage after day 28 | When was the last day of opioid usage | Assessment within 1 year |
| Amount of opioid usage after 28 days | Milligram of morphine equivalent use weekly after 28 days | 28 days to 1 year after surgery |
| Patient satisfaction | Assessing patient's satisfaction, using the standardized -Quality of Recovery 15- at post operative day 7, 28 and 1 year. Each item count on a 0-10 scale where O is worse and 10 is best PART A How have you been feeling in the last 24 hours? (0 to 10, where 0 = none of the time [poor] and 10 = all of the time [excellent] Q.1 Able to breathe easily Q.2 Been able to enjoy food Q.3 Feeling rested Q.4 Have had a good sleep Q.5 Able to look after personal toilet and hygiene unaided Q.6 Able to communicate with family or friends Q.7 Getting support from hospital doctors and nurses Q.8 Able to return to work or usual home activities Q.9 Feeling comfortable and in control Q.10 Having a feeling of general well-being PART B Have you had any of the following in the last 24 hours? (10 to 0, where 10 = none of the time [excellent] and 0 = all of the time [poor]) Q.11 Moderate pain Q.12 Severe pain Q.13 Nausea or vomiting Q.14 Feeling worried or anxious Q.15 Feeling sad or depressed | At Post Operative day 7, 28 and 1 year |
| General satisfaction | General satisfaction on a scale from 1-5 (extremely unsatisfied, unsatisfied, neutral, satisfy, extremely satisfied) | at post operative day 7, 28 and 1 year |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |