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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01HL160761-03 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise, to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to compare the association between indices of disease severity and hemodynamic abnormalities identified at rest versus exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients Undergoing Clinically indicated Cardiac Cath | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac Cath | Procedure | Patient will undergo standard of care Cardiac Cath and in addition invasive CPET (Cardiopulmonary exercise testing) will be performed during the procedure. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in left ventricular end-systolic elastance from rest to peak exercise | Change in left ventricular end-systolic elastance will be measured in ΔmmHg/mL | Baseline |
| Change in Left ventricular cardiac output from rest to peak exercise | Change in left ventricular cardiac output will be measured in ΔL/min | Baseline |
| Change in systemic vascular resistance from rest to peak exercise | Change in systemic vascular resistance will be measured in ΔWoods Units | Baseline |
| Change in right ventricular free-wall strain from rest to peak exercise | Change in right ventricular free-wall strain will be measured in Δ% | Baseline |
| Change in right ventricular cardiac output from rest to peak exercise | Change in right ventricular cardiac output will be measured in ΔL/min | Baseline |
| Change in pulmonary vascular resistance from rest to peak exercise | Change in pulmonary vascular resistance will be measured in ΔWoods Units | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ACHD Research Program | Contact | 507-293-2565 | RSTACHDRESPRG@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Alexander Egbe, M.B.B.S., M.P.H. | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Recruiting | Rochester | Minnesota | 55905 | United States |
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| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |